Identification of DNA methylation prognostic signature of acute myelocytic leukemia

DNA methylation as a prognostic marker in acute lymphoblastic leukemia

iii Populärvetenskaplig sammanfattning iv DNA metylering i akut lymfatisk leukemi iv

DNA Methylation and Its Role in the Development of Leukemia

Epigenetic changes play an essential role in cancer pathogenesis. It has been established by next-generation sequencing that more than 50% of the human cancers carry mutations in mechanisms involved in the organization of the chromatin and epigenetic regulations. DNA methylation is among the most common epigenetic changes in leukemia. In contrast to DNA mutations which are passively inherited f...

Methylation Status of SOX17 and RUNX3 Genes in Acute Leukemia

Background: Several studies have examined the presence of DNA methylation of CpG islands in leukemia. Methylation of SOX17 and RUNX3 genes may play a role in leukemogenesis through silencing tumor suppressor genes. We investigated the methylation status of SOX17 and RUNX3 genes in patients with acute leukemia.    Methods: In this case-control study, peripheral blood samples from 100 AML and 10...

DNA Methylation in Acute Leukemia

Intracerebral hemorrhagic dissemination of acute myelocytic leukemia.

A 10-year-old boy was admitted with left leg pain and fever of 38.9°C. The initial clinical impression was cellulitis. Laboratory findings included hemoglobin of 5 gjdl and white blood cell count of 206,OOOjmma The spleen was enlarged and multiple cervical lymph nodes were palpable. Bone marrow pathology was interpreted as acute myelocytic leukemia. The child was treated with antibiotics , but ...